Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.42 |
| ▸ | PDE4A | P27815 | 16/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11091127 | 0.87 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL2868054 | 0.84 | MAPT (0.39) | KMT2ALMNA | |
| SCHEMBL7466462 | 0.81 | PDE4A (0.51) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL521949 | 0.80 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL5703617 | 0.80 | PDE4A (0.68) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7416606 | 0.79 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL11092765 | 0.79 | ALDH1A1 (0.48) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL31737590 | 0.79 | SIRT6 (0.48) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL3522150 | 0.79 | SLC6A4 (0.54) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7415505 | 0.78 | PDE4A (0.45) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | PDE4B 2705/4885PDE4A 2376/4885PDE4C 3309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.