Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 3/20 | 0.54 |
| ▸ | WNT3A | P56704 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175067 | 0.89 | HDAC3 (0.51) | CTNNB1WNT3ATSHRHDAC3HDAC4 | |
| SCHEMBL341128 | 0.88 | MGAM (0.60) | TSHRL3MBTL1NPSR1ALDH1A1HSD17B10 | |
| SCHEMBL30583856 | 0.88 | MGAM (0.60) | TSHRL3MBTL1NPSR1ALDH1A1HSD17B10 | |
| SCHEMBL11985714 | 0.84 | CTNNB1 (0.51) | CTNNB1WNT3AHDAC3HDAC4HDAC1 | |
| SCHEMBL2895789 | 0.83 | CTNNB1 (0.58) | CTNNB1WNT3AHDAC3HDAC4HDAC1 | |
| SCHEMBL28753366 | 0.80 | HDAC3 (0.63) | CTNNB1WNT3AHDAC3HDAC4HDAC1 | |
| SCHEMBL12599573 | 0.78 | TSHR (0.49) | TSHRL3MBTL1NPSR1ALDH1A1HSD17B10 | |
| SCHEMBL1612190 | 0.77 | TSHR (0.49) | TSHRL3MBTL1NPSR1ALDH1A1HSD17B10 | |
| SCHEMBL19973511 | 0.77 | TSHR (0.49) | TSHRL3MBTL1NPSR1ALDH1A1HSD17B10 | |
| SCHEMBL6677783 | 0.77 | TSHR (0.49) | TSHRL3MBTL1NPSR1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |
| EP-1137644-B9 | BENZOFURAN DERIVATIVES, THEIR PREPARATION AND USE | LUNDBECK & CO AS H (DK) | 2004-03-17 | — | — | EP | disclosed |
| EP-1137644-B1 | BENZOFURAN DERIVATIVES, THEIR PREPARATION AND USE | LUNDBECK & CO AS H (DK) | 2003-09-10 | — | — | EP | disclosed |
| US-6492374-B2 | AN ALKYL AMINE SUBSTITUTED ISOBENZOFURAN COMPOUND USEFUL FOR CERTAIN PSYCHIATRIC AND NEUROLOGICAL DISORDERS; POTENTLY BINDING TO THE 5-HT1A RECEPTOR | H. LUNDBECK A/S (DK) | 2002-12-10 | — | — | US | disclosed |
| US-20020032205-A1 | Benzofuran derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-03-14 | — | — | US | disclosed |
| EP-1137644-A1 | BENZOFURAN DERIVATIVES, THEIR PREPARATION AND USE | H. Lundbeck A/S (DK) | 2001-10-04 | — | — | EP | disclosed |
| EP-1112270-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-07-04 | — | — | EP | disclosed |
| US-6172062-B1 | ANTISEROTONIN AGENTS; GASTROINTESTINAL DISORDERS; CARDIOVASCULAR DISORDERS; NERVOUS SYSTEM DISORDERS | SYNTEX (USA) LLC | 2001-01-09 | — | — | US | disclosed |
| WO-2000034263-A1 | BENZOFURAN DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2000-06-15 | — | — | WO | disclosed |
| WO-2000015636-A1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032205-A1 | Benzofuran derivatives, their preparation and use | HTR1F, HTR1A, HTR1D | CTNNB1 1142/4885WNT3A 1957/4885TSHR 1040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.