Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | HTR1F | P30939 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 9/20 | 0.59 |
| ▸ | NPC1 | O15118 | 9/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215660 | 0.86 | HTR1F (0.60) | PKMALOX15HTR1FNPC1SMN1; SMN2 | |
| SCHEMBL5214917 | 0.84 | HTR1F (0.67) | PKMALOX15HTR1FEPHX2MEN1 | |
| SCHEMBL5215939 | 0.84 | HTR1F (0.67) | HTR1FEPHX2MEN1KMT2AGAA | |
| SCHEMBL5211976 | 0.84 | HTR1F (0.64) | HTR1FSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5210817 | 0.82 | HTR1F (0.65) | HTR1FRAB9ANPC1KMT2A | |
| SCHEMBL14395081 | 0.82 | HTR1F (0.70) | HTR1FMEN1KMT2AALDH1A1 | |
| SCHEMBL4962264 | 0.81 | PKM (1.00) | PKMALOX15RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5216477 | 0.81 | HTR1F (0.64) | HTR1FRAB9ANPC1SMN1; SMN2EPHX2 | |
| SCHEMBL5214297 | 0.81 | HTR1F (0.64) | HTR1FRAB9ANPC1SMN1; SMN2EPHX2 | |
| SCHEMBL5211786 | 0.81 | HTR1F (0.73) | HTR1FRAB9ANPC1EPHX2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153013-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1153013-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2007-10-31 | — | — | EP | disclosed |
| US-6777428-B1 | INHIBIT PEPTIDE EXTRAVASATION DUE TO STIMULATION OF THE TRIGEMINAL GANGLIA, AND ARE THEREFORE USEFUL FOR THE TREATMENT OF MIGRAINE AND ASSOCIATED DISORDERS | ELI LILLY AND COMPANY | 2004-08-17 | — | — | US | disclosed |
| EP-1153013-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2000047559-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-08-17 | — | — | WO | disclosed |