Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | TACR2 | P21452 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KMT5B | Q4FZB7 | 1/20 | 0.38 |
| ▸ | KMT5C | Q86Y97 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212553 | 0.89 | GAA (0.42) | GAAADORA3ADORA2AADORA1FYN | |
| SCHEMBL5459554 | 0.88 | ALOX5 (0.42) | GAAALDH1A1MAPTALOX5MAPK14 | |
| SCHEMBL6105851 | 0.86 | MAPT (0.42) | ALDH1A1MAPTGFERSMN1; SMN2ALOX5 | |
| SCHEMBL6105090 | 0.85 | TP53 (0.47) | GAAALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL5217016 | 0.84 | HTT (0.39) | GAAALDH1A1MAPTGFERSMN1; SMN2 | |
| SCHEMBL5217022 | 0.84 | HTT (0.39) | GAAALDH1A1MAPTGFERSMN1; SMN2 | |
| SCHEMBL5451038 | 0.82 | MAPT (0.35) | GAAALDH1A1MAPTKDM4EFYN | |
| SCHEMBL6104272 | 0.82 | PIM1 (0.40) | ALDH1A1MAPTSMN1; SMN2FYNRAB9A | |
| SCHEMBL6106788 | 0.81 | ALDH1A1 (0.38) | GAAALDH1A1MAPTHTTADORA3 | |
| SCHEMBL6104555 | 0.80 | ATM (0.40) | ALDH1A1MAPTALOX5KDM4EFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453830-B1 | PYRAZOLO-PYRIDINE DERIVATIVES AS ANTIHERPES AGENTS | SMITHKLINE BEECHAM CORP (US) | 2007-09-12 | — | — | EP | disclosed |
| US-20070161653-A1 | Pyrazolo-Pyridine Derivatives As Antiherpes Agents | GUDMUNDSSON KRISTJAN | 2007-07-12 | — | — | US | disclosed |
| US-7199120-B2 | Pyrazolo-pyridine derivatives as antiherpes agents | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-20040248903-A1 | Pyrazolo-pyridine derivatives as antiherpes agents | SMITHKLINE BEECHAM CORPORATION | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161653-A1 | Pyrazolo-Pyridine Derivatives As Antiherpes Agents | HRH4, HRH2, HRH1 | GAA 1319/4885ALDH1A1 164/4885MAPT 1616/4885 |
| US-20040248903-A1 | Pyrazolo-pyridine derivatives as antiherpes agents | HRH4, HRH1, HRH2 | GAA 1480/4885ALDH1A1 132/4885MAPT 1457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.