SCHEMBL5212872

SCHEMBL5212872

Cc1nc2c(OCc3ccccc3)cc(Br)cn2c1C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATP4A P20648 5/20 0.52
ATP4B P51164 5/20 0.52
CYP3A4 P08684 3/20 0.48
CYP2C9 P11712 3/20 0.48
CYP1A2 P05177 3/20 0.48
CYP2D6 P10635 2/20 0.48
MAPK1 P28482 2/20 0.48
MEN1 O00255 1/20 0.48
BLM P54132 1/20 0.48
PMP22 Q01453 1/20 0.48
KMT2A Q03164 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
STAT3 P40763 1/20 0.46
HTT P42858 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
CYP2C19 P33261 1/20 0.44
MCHR1 Q99705 1/20 0.43
PTGER1 P34995 3/20 0.43
GCK P35557 1/20 0.42
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4881836 0.86 CYP3A4 (0.41) ATP4AATP4BCYP3A4CYP2C9CYP1A2
SCHEMBL5034255 0.84 ATP4A (0.51) ATP4AATP4BCYP3A4CYP2C9CYP1A2
SCHEMBL4891085 0.84 CYP3A4 (0.65) CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19
SCHEMBL5216426 0.84 ATP4A (0.58) ATP4AATP4BCYP3A4CYP2C9CYP1A2
SCHEMBL4591666 0.81 ATP4A (0.50) ATP4AATP4BCYP3A4CYP2C9CYP1A2
SCHEMBL19492086 0.81 ATP4A (0.45) ATP4AATP4BCYP3A4CYP2C9CYP1A2
SCHEMBL15663898 0.81 MAPK1 (0.51) ATP4AATP4BCYP3A4CYP2C9CYP1A2
SCHEMBL2193469 0.79 ATP4A (0.76) ATP4AATP4BCYP3A4CYP2C9CYP1A2
SCHEMBL5423755 0.78 GCK (0.46) ATP4AATP4BCYP1A2MAPK1MEN1
SCHEMBL5037317 0.78 BRD4 (0.50) ATP4AATP4BCYP3A4CYP2C9CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7223771-B2 Tricyclic imidazopyridines ALTANA PHARMA AG (DE) 2007-05-29 US disclosed
US-7223771-B2 Tricyclic imidazopyridines ALTANA PHARMA AG (DE) 2007-05-29 US disclosed
US-7223771-B2 Tricyclic imidazopyridines ALTANA PHARMA AG (DE) 2007-05-29 US disclosed
US-7189736-B2 Prodrugs of imidazopyridine derivatives ALTANA PHARMA AG (DE) 2007-03-13 US disclosed
US-7189736-B2 Prodrugs of imidazopyridine derivatives ALTANA PHARMA AG (DE) 2007-03-13 US disclosed
US-7189736-B2 Prodrugs of imidazopyridine derivatives ALTANA PHARMA AG (DE) 2007-03-13 US disclosed
EP-1303519-B1 TRICYCLIC IMIDAZOPYRIDINES ALTANA PHARMA AG (DE) 2007-03-07 EP disclosed
EP-1303519-B1 TRICYCLIC IMIDAZOPYRIDINES ALTANA PHARMA AG (DE) 2007-03-07 EP disclosed
US-7141567-B2 Polysubstituted imidazopyridines as gastric secretion inhibitors ALTANA PHARMA AG (DE) 2006-11-28 US disclosed
EP-1313739-B1 ALKYLATED IMIDAZOPYRIDINE DERIVATIVES ALTANA PHARMA AG (DE) 2006-07-05 EP disclosed
EP-1313739-A1 ALKYLATED IMIDAZOPYRIDINE DERIVATIVES ALTANA Pharma AG (DE) 2003-05-28 EP disclosed
EP-1303519-A1 TRICYCLIC IMIDAZOPYRIDINES ALTANA Pharma AG (DE) 2003-04-23 EP disclosed
WO-2001072748-A9 IMIDAZOPYRIDIN-8-ONES ALTANA PHARMA AG (DE) 2003-04-10 WO disclosed
EP-1286993-A1 IMIDAZOPYRIDIN-8-ONES ALTANA Pharma AG (DE) 2003-03-05 EP disclosed
WO-2003014123-A1 TRICYCLIC IMIDAZOPYRIDINES ALTANA PHARMA AG (DE) 2003-02-20 WO disclosed
WO-2002034749-A1 POLYSUBSTITUTED IMIDAZOPYRIDINES AS GASTRIC SECRETION INHIBITORS ALTANA PHARMA AG (DE) 2002-05-02 WO disclosed
WO-2001072757-A1 TRICYCLIC IMIDAZOPYRIDINES ALTANA PHARMA AG (DE) 2001-10-04 WO disclosed
WO-2001072756-A1 PRODRUGS OF IMIDAZOPYRIDINE DERIVATIVES ALTANA PHARMA AG (DE) 2001-10-04 WO disclosed
WO-2001072754-A1 ALKYLATED IMIDAZOPYRIDINE DERIVATIVES ALTANA PHARMA AG (DE) 2001-10-04 WO disclosed
WO-2001072748-A1 IMIDAZOPYRIDIN-8-ONES ALTANA PHARMA AG (DE) 2001-10-04 WO disclosed