Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | ATP4A | P20648 | 2/20 | 0.40 |
| ▸ | ATP4B | P51164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 5/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212872 | 0.86 | ATP4A (0.52) | CYP3A4CYP2C9ATP4AATP4BRAB9A | |
| SCHEMBL4877737 | 0.80 | RAB9A (0.43) | NPC1RAB9ACSF1RNTRK1NTRK3 | |
| SCHEMBL31211004 | 0.79 | AKT1 (0.40) | CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4881671 | 0.79 | SNCA (0.37) | CYP3A4CYP2C9ATP4AATP4BNPC1 | |
| SCHEMBL4891085 | 0.78 | CYP3A4 (0.65) | CYP3A4CYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4886747 | 0.78 | CYP3A4 (0.71) | CYP3A4CYP2C9ATP4AATP4BCYP1A2 | |
| SCHEMBL1584139 | 0.76 | HDAC8 (0.42) | CYP3A4CYP2C9CYP1A2CYP2C19HDAC8 | |
| SCHEMBL4882498 | 0.76 | CYP3A4 (0.52) | CYP3A4CYP2C9ATP4AATP4BNPC1 | |
| SCHEMBL12996950 | 0.74 | CYP2C9 (0.42) | CYP3A4CYP2C9NPC1RAB9ACYP1A2 | |
| SCHEMBL12996957 | 0.74 | PTGS2 (0.43) | CYP3A4CYP2C9CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100311740-A1 | IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-12-09 | — | — | US | disclosed |
| US-20100311740-A1 | IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-12-09 | — | — | US | disclosed |
| US-20080255358-A1 | Derivatives of Imidazo [1,2-A] Pyridine Useful as Medicaments For Treating Gastrointestinal Diseases | GLAXO GROUP LIMITED (GB) | 2008-10-16 | — | — | US | disclosed |
| US-20080255358-A1 | Derivatives of Imidazo [1,2-A] Pyridine Useful as Medicaments For Treating Gastrointestinal Diseases | GLAXO GROUP LIMITED (GB) | 2008-10-16 | — | — | US | disclosed |
| WO-2007003386-A9 | IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-09-18 | — | — | WO | disclosed |
| WO-2007003386-A1 | IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255358-A1 | Derivatives of Imidazo [1,2-A] Pyridine Useful as Medicaments For Treating Gastrointestinal Diseases | ALPI, PYGL, PPIP5K2 | CYP3A4 215/4885CYP2C9 1357/4885ATP4A 392/4885 |
| US-20100311740-A1 | IMIDAZOPYRIDINE DERIVATIVES AS ACID PUMP ANTAGONISTS | HRH2, GIPR, MLNR | CYP3A4 151/4885CYP2C9 585/4885ATP4A 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.