Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 10/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210617 | 0.87 | HTR1F (0.66) | HTR1FKMT2AMEN1NPSR1MGLL | |
| SCHEMBL14394945 | 0.86 | HTR1F (0.69) | HTR1FKMT2AMEN1NPSR1 | |
| SCHEMBL5210214 | 0.85 | HTR1F (0.63) | HTR1FKMT2AMEN1NPSR1MGLL | |
| SCHEMBL5208521 | 0.85 | HTR1F (0.63) | HTR1FKMT2AMEN1NPSR1MGLL | |
| SCHEMBL14395081 | 0.85 | HTR1F (0.70) | HTR1FKMT2AMEN1 | |
| SCHEMBL4223030 | 0.84 | MGLL (0.59) | HTR1FKMT2AMEN1NPSR1MGLL | |
| Oxalic Acid SCHEMBL5210431 | 0.84 | HTR1F (0.62) | HTR1FKMT2AMEN1NPSR1MGLL | |
| Hydrochloric Acid SCHEMBL5212124 | 0.83 | MGLL (0.57) | HTR1FKMT2AMEN1NPSR1MGLL | |
| SCHEMBL5214917 | 0.83 | HTR1F (0.67) | HTR1FKMT2AMEN1 | |
| SCHEMBL5215939 | 0.83 | HTR1F (0.67) | HTR1FKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153013-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2007-10-31 | — | — | EP | disclosed |
| US-6777428-B1 | INHIBIT PEPTIDE EXTRAVASATION DUE TO STIMULATION OF THE TRIGEMINAL GANGLIA, AND ARE THEREFORE USEFUL FOR THE TREATMENT OF MIGRAINE AND ASSOCIATED DISORDERS | ELI LILLY AND COMPANY | 2004-08-17 | — | — | US | disclosed |
| EP-1153013-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2000047559-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-08-17 | — | — | WO | disclosed |