Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 5/20 | 0.72 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.72 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.72 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.72 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.72 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5449139 | 0.87 | CHRNB4 (0.58) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL6586885 | 0.85 | CHRNB1 (1.00) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| Hydrochloric Acid SCHEMBL6588461 | 0.84 | CHRNB1 (0.98) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL6192460 | 0.84 | CHRNB2 (0.63) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL6192462 | 0.84 | CHRNB2 (0.63) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL3598905 | 0.83 | CHRNB4 (0.69) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL9238637 | 0.83 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL9238640 | 0.83 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL9242124 | 0.83 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 | |
| SCHEMBL9243817 | 0.83 | CHRNB4 (0.72) | CHRNB4CHRNA3CHRNB2CHRNB1CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | CHRNB4 4585/4885CHRNA3 4475/4885CHRNB2 4788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.