Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 8/20 | 0.80 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5210296 | 0.92 | HTR1F (0.71) | HTR1FPTGS1ACKR3MAPTLMNA | |
| SCHEMBL30908870 | 0.89 | HTR1F (1.00) | HTR1FMEN1KMT2A | |
| SCHEMBL5210537 | 0.89 | HTR1F (1.00) | HTR1FMEN1KMT2A | |
| SCHEMBL5216542 | 0.88 | HTR1F (0.82) | HTR1FMEN1KMT2ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5214792 | 0.88 | HTR1F (0.98) | HTR1FMEN1KMT2A | |
| SCHEMBL5214770 | 0.87 | HTR1F (0.81) | HTR1FACKR3MAPTMEN1KMT2A | |
| SCHEMBL14395095 | 0.87 | HTR1F (0.81) | HTR1FMEN1KMT2A | |
| SCHEMBL5212621 | 0.87 | HTR1F (0.74) | HTR1FLMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14395094 | 0.86 | HTR1F (0.76) | HTR1FACKR3LMNAMEN1KMT2A | |
| SCHEMBL5212810 | 0.86 | HTR1F (0.79) | HTR1FMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153013-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2007-10-31 | — | — | EP | disclosed |
| US-6777428-B1 | INHIBIT PEPTIDE EXTRAVASATION DUE TO STIMULATION OF THE TRIGEMINAL GANGLIA, AND ARE THEREFORE USEFUL FOR THE TREATMENT OF MIGRAINE AND ASSOCIATED DISORDERS | ELI LILLY AND COMPANY | 2004-08-17 | — | — | US | disclosed |
| EP-1153013-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2000047559-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-08-17 | — | — | WO | disclosed |