Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.58 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.58 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.54 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214686 | 0.92 | HTR1F (0.80) | HTR1FALDH1A1TP53PTGS1MEN1 | |
| SCHEMBL5210602 | 0.88 | HTR1F (0.59) | HTR1FALDH1A1TP53MEN1KMT2A | |
| Oxalic Acid SCHEMBL5212893 | 0.85 | HTR1F (0.58) | HTR1FALDH1A1TP53MEN1HTT | |
| SCHEMBL5213369 | 0.85 | HTR1F (0.83) | HTR1FMEN1HTTRAB9AKMT2A | |
| SCHEMBL5215041 | 0.85 | HTR1F (0.69) | HTR1FALDH1A1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL5216542 | 0.85 | HTR1F (0.82) | HTR1FMEN1RAB9AKMT2AKCNK3 | |
| SCHEMBL5208639 | 0.84 | HTR1F (0.73) | HTR1FMEN1RAB9AKMT2AKCNK3 | |
| SCHEMBL5213663 | 0.83 | HTR1F (0.80) | HTR1FMEN1KMT2AACKR3 | |
| SCHEMBL5210217 | 0.83 | ALDH1A1 (0.57) | HTR1FALDH1A1MEN1HTTKMT2A | |
| SCHEMBL5210537 | 0.83 | HTR1F (1.00) | HTR1FMEN1KMT2AKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153013-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2007-10-31 | — | — | EP | disclosed |
| US-6777428-B1 | INHIBIT PEPTIDE EXTRAVASATION DUE TO STIMULATION OF THE TRIGEMINAL GANGLIA, AND ARE THEREFORE USEFUL FOR THE TREATMENT OF MIGRAINE AND ASSOCIATED DISORDERS | ELI LILLY AND COMPANY | 2004-08-17 | — | — | US | disclosed |
| CN-1149195-C | 5-HTIF agonists | — | 2004-05-12 | — | — | CN | disclosed |
| EP-1153013-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2001-11-14 | — | — | EP | disclosed |
| WO-2000047559-A2 | 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-08-17 | — | — | WO | disclosed |