Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214876 | 0.82 | MAPT (0.57) | KMT2AMEN1HSD17B10MAPTUSP2 | |
| SCHEMBL4381893 | 0.74 | MEN1 (0.68) | KMT2AMEN1HSD17B10MAPTUSP2 | |
| SCHEMBL4382056 | 0.74 | MEN1 (0.68) | KMT2AMEN1HSD17B10MAPTUSP2 | |
| SCHEMBL10476 | 0.74 | MEN1 (0.68) | KMT2AMEN1HSD17B10MAPTUSP2 | |
| SCHEMBL7571912 | 0.74 | — | — | |
| SCHEMBL4382567 | 0.74 | KDM4E (0.51) | KMT2AMEN1HSD17B10MAPTUSP2 | |
| SCHEMBL3276166 | 0.74 | KDM4E (0.51) | KMT2AMEN1HSD17B10MAPTUSP2 | |
| SCHEMBL4375597 | 0.74 | KDM4E (0.51) | KMT2AMEN1HSD17B10MAPTUSP2 | |
| SCHEMBL7137154 | 0.73 | ALDH1A1 (0.50) | MAPTHTTSMN1; SMN2ALDH1A1PKM | |
| SCHEMBL11701515 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453492-B1 | USE OF QUINAZOLINES TO TREAT T-CELL MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2007-01-24 | — | — | EP | disclosed |