Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10500232 | 0.98 | RECQL (0.41) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL29521056 | 0.98 | RECQL (0.41) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL5215315 | 0.94 | RECQL (0.41) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL29521086 | 0.82 | HTR2C (0.41) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL29520731 | 0.82 | RECQL (0.38) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL8470553 | 0.82 | HTR2C (0.41) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL29520805 | 0.82 | LRRK2 (0.47) | RECQLPOLBNPSR1LRRK2TSHR | |
| Hydrochloric Acid SCHEMBL10583863 | 0.81 | ADRA2A (0.41) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL4788217 | 0.78 | ADRA2A (0.38) | RECQLCYP1A2ADRA2AADRA2BADRA2C | |
| SCHEMBL14911964 | 0.76 | NPC1 (0.44) | POLBALDH1A1HPGDHSD17B10GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458982-A | Indazole compounds as irak4 inhibitors | 奥列基因发现技术有限公司 | 2017-02-22 | — | — | CN | disclosed |
| EP-3092226-A1 | INDAZOLE COMPOUNDS AS IRAK4 INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2016-11-16 | — | — | EP | disclosed |
| WO-2015104662-A1 | INDAZOLE COMPOUNDS AS IRAK4 INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-07-16 | — | — | WO | disclosed |
| EP-0192935-B1 | 3-(PIPERIDINYL)-1H-INDAZOLES A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-02-27 | — | — | EP | disclosed |
| EP-0192935-A1 | 3-(piperidinyl)-1H-indazoles a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-09-03 | — | — | EP | disclosed |