Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CCR2 | P41597 | 3/20 | 0.48 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213680 | 0.81 | CCR2 (0.65) | ALDH1A1HPGDGAAKDM4ESMN1; SMN2 | |
| SCHEMBL5213738 | 0.80 | P2RX7 (0.49) | HPGDTSHRGAASMN1; SMN2CCR2 | |
| SCHEMBL6302584 | 0.80 | CCR2 (0.62) | ALDH1A1HPGDGAAKMT2AMEN1 | |
| SCHEMBL5214863 | 0.80 | CCR2 (0.76) | ALDH1A1HPGDGAAKDM4ESMN1; SMN2 | |
| SCHEMBL5217008 | 0.78 | CCR2 (0.48) | ALDH1A1HPGDTSHRGAAKMT2A | |
| SCHEMBL5220576 | 0.77 | CCR2 (0.61) | ALDH1A1HPGDGAAKDM4ESMN1; SMN2 | |
| SCHEMBL5216535 | 0.75 | CCR2 (0.59) | ALDH1A1HPGDTSHRGAASMN1; SMN2 | |
| SCHEMBL5214927 | 0.75 | CCR2 (0.59) | ALDH1A1HPGDTSHRGAAKMT2A | |
| SCHEMBL8688955 | 0.75 | CCR2 (0.59) | ALDH1A1HPGDTSHRGAAKMT2A | |
| SCHEMBL5214254 | 0.74 | CCR2 (0.52) | ALDH1A1HPGDGAAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173421-B1 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | ASTRAZENECA AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| US-6833387-B1 | 3-substituted indoles; inhibition of monocyte chemoattractant protein-1 and/or RANTES induced chemotaxis; inflammatory diseases | ASTRAZENECA AB (SE) | 2004-12-21 | — | — | US | disclosed |
| EP-1173421-A2 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000046199-A2 | INDOLE DERIVATIVES AS ANTI-INFLAMMATION AGENTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |