Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.45 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.45 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5216512 | 1.00 | LMNA (0.53) | LMNACYP11B1CYP11B2GAATP53 | |
| SCHEMBL4679717 | 0.81 | LMNA (0.53) | LMNACYP11B1CYP11B2GAATP53 | |
| SCHEMBL2801168 | 0.81 | LMNA (0.53) | LMNACYP11B1CYP11B2GAATP53 | |
| SCHEMBL2801166 | 0.81 | LMNA (0.53) | LMNACYP11B1CYP11B2GAATP53 | |
| SCHEMBL7898824 | 0.81 | LMNA (0.53) | LMNACYP11B1CYP11B2GAATP53 | |
| SCHEMBL11156357 | 0.79 | RAB9A (0.57) | LMNACYP11B1CYP11B2GAATP53 | |
| SCHEMBL4685504 | 0.78 | LMNA (0.54) | LMNACYP11B1CYP11B2GAATP53 | |
| SCHEMBL4685507 | 0.78 | LMNA (0.54) | LMNACYP11B1CYP11B2GAATP53 | |
| SCHEMBL162151 | 0.77 | LMNA (0.52) | LMNACYP11B1CYP11B2GAATP53 | |
| SCHEMBL162150 | 0.77 | LMNA (0.52) | LMNACYP11B1CYP11B2GAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1198456-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2007-09-19 | — | — | EP | disclosed |