Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224020 | 0.84 | NPC1 (0.39) | CYP2C9KMT2AMEN1POLBHTT | |
| SCHEMBL5216688 | 0.81 | HTT (0.36) | CYP2C9KMT2AMEN1POLBHTT | |
| SCHEMBL5690739 | 0.76 | SIRT2 (0.42) | KMT2AMEN1HTTLMNAMAPT | |
| SCHEMBL5682164 | 0.75 | CYP11B1 (0.43) | KMT2ACYP1A2 | |
| SCHEMBL5220589 | 0.74 | CYP2C9 (0.40) | CYP2C9KMT2AMEN1POLBHTT | |
| SCHEMBL5220582 | 0.73 | CYP2C9 (0.39) | CYP2C9KMT2AMEN1POLBHTT | |
| SCHEMBL2916350 | 0.73 | PRKAA2 (0.37) | KMT2AMEN1POLBLMNAMAPT | |
| SCHEMBL10944422 | 0.73 | CYP2C9 (0.57) | CYP2C9KMT2AMEN1POLBHTT | |
| SCHEMBL8545653 | 0.72 | KDM4E (0.44) | POLBLMNAMAPTTSHRSMN1; SMN2 | |
| SCHEMBL4030987 | 0.71 | MEN1 (0.51) | KMT2AMEN1CYP1A2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458386-B1 | AROYL PYRROLE HETEROERYL AND METHANOLS USEFUL FOR TREATING A CENTRAL NERVOUS SYSTEM DISORDER | ORTHO MCNEIL PHARM INC (US) | 2007-04-18 | — | — | EP | disclosed |
| US-20050148636-A1 | Useful aroyl pyrrole heteroaryl methanones and methanols | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-07-07 | — | — | US | disclosed |
| US-6897319-B2 | Useful aroyl pyrrole heteroaryl methanones and methanols | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-05-24 | — | — | US | disclosed |
| EP-1458386-A1 | AROYL PYRROLE HETEROERYL AND METHANOLS USEFUL FOR TREATING A CENTRAL NERVOUS SYSTEM DISORDER | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-09-22 | — | — | EP | disclosed |
| US-20040058980-A1 | Useful aroyl pyrrole heteroaryl methanones and methanols | ORTHO-MCNEIL PHARMACEUTICALS, INC. | 2004-03-25 | — | — | US | disclosed |
| US-20030181481-A1 | Useful aroyl pyrrole heteroaryl methanones and methanols | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-09-25 | — | — | US | disclosed |
| WO-2003057219-A1 | AROYL PYRROLE HETEROERYL AND METHANOLS USEFUL FOR TREATING A CENTRAL NERVOUS SYSTEM DISORDER | ORTHO-MCNEIL PHARMACEUTICAL INC. (US) | 2003-07-17 | — | — | WO | disclosed |
| WO-2003057147-A2 | USEFUL AROYL PYRROLE HETEROARYL METHANONES AND METHANOLS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-07-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148636-A1 | Useful aroyl pyrrole heteroaryl methanones and methanols | CYP11B2, NLN, CNR2 | CYP2C9 521/4885KMT2A 2816/4885MEN1 706/4885 |
| US-20040058980-A1 | Useful aroyl pyrrole heteroaryl methanones and methanols | CYP11B2, NLN, CNR2 | CYP2C9 521/4885KMT2A 2816/4885MEN1 706/4885 |
| US-20030181481-A1 | Useful aroyl pyrrole heteroaryl methanones and methanols | CYP11B2, NLN, CNR2 | CYP2C9 521/4885KMT2A 2816/4885MEN1 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.