Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542771 | 0.81 | PSEN1 (0.52) | HPGDALDH1A1HSD17B10 | |
| SCHEMBL8540560 | 0.78 | PSEN1 (0.47) | HPGDALDH1A1HSD17B10 | |
| SCHEMBL8539326 | 0.77 | PDE10A (0.36) | HSD17B10RXRARXRBTSHR | |
| SCHEMBL5682164 | 0.77 | CYP11B1 (0.43) | — | |
| SCHEMBL1414929 | 0.77 | SIRT2 (0.36) | HPGDALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL5690739 | 0.75 | SIRT2 (0.42) | KDM4EHPGDALDH1A1MAPTNPC1 | |
| SCHEMBL4030987 | 0.75 | MEN1 (0.51) | MAPTNPC1RAB9ASMN1; SMN2CNR2 | |
| SCHEMBL8540731 | 0.75 | KIF11 (0.46) | KDM4EHPGDALDH1A1MAPTNPC1 | |
| SCHEMBL5678341 | 0.75 | KDM4E (0.46) | KDM4EHPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL4024355 | 0.75 | SIRT2 (0.41) | MAPTNPC1RAB9ASMN1; SMN2ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820989-A1 | IMIDAZOLE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |