Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dienestrol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | NR3C1 | P04150 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dienestrol SCHEMBL2896853 | 1.00 | ESR1 (1.00) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL2896848 | 1.00 | ESR1 (1.00) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL9317394 | 0.97 | ESR1 (0.94) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL3716190 | 0.95 | ESR1 (0.90) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL8425094 | 0.92 | ESR1 (0.85) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL6573104 | 0.92 | ESR1 (0.85) | ESR1MAPTLMNAHSD17B10MEN1 | |
| SCHEMBL13492676 | 0.90 | MAPT (0.81) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL114016 | 0.90 | ESR1 (0.81) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL8854079 | 0.84 | ESR1 (0.71) | ESR1MAPTLMNAHSD17B10MEN1 | |
| SCHEMBL15721373 | 0.84 | MAPT (0.71) | ESR1MAPTLMNAHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6312 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119822938-B | Method for synthesizing 2- (3-hydroxypropyl) cyclododecanone | 万华化学集团股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122010729-A | Continuous production process of E-conjugated diene alcohol ester compound | 现代纺织技术创新中心(鉴湖实验室) | 2026-05-12 | — | — | CN | claimed |
| US-20260109699-A1 | AZOLE DERIVATIVES AS SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2026-04-23 | — | — | US | claimed |
| US-20250262146-A1 | PLATFORM NANOPARTICLE TECHNOLOGY FOR SUSTAINED DELIVERY OF HYDROPHOBIC DRUGS | UNIVERSITY OF MARYLAND, BALTIMORE | 2025-08-21 | — | — | US | claimed |
| US-20250250253-A1 | SALT FORMS AND POLYMORPHS OF (R)-1-(4-(6-(2-(4-(3,3-DIFLUOROCYCLOBUTOXY)-6-METHYLPYRIDIN-2-YL)ACETAMIDO) PYRIDAZIN-3-YL)-2-FLUOROBUTYL)-N-METHYL-1H-1,2,3-TRIAZOLE-4-CARBOXAMIDE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2025-08-07 | — | — | US | claimed |
| EP-4594324-A1 | AZOLE DERIVATIVES AS SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2025-08-06 | — | — | EP | claimed |
| CN-116649335-B | Intelligent slow-release material based on photo-thermal conversion and preparation and application thereof | 中国人民大学 | 2025-06-03 | — | — | CN | claimed |
| CN-117337840-B | Application of benzyl cyanide as attractant synergist of bark beetle in larch | 中国林业科学研究院森林生态环境与自然保护研究所(国家林业和草原局世界自然遗产保护研究中心) | 2025-05-30 | — | — | CN | claimed |
| CN-120004912-A | Tricyclic prostaglandin D2Preparation method of metabolite methyl ester | 南华大学 | 2025-05-16 | — | — | CN | claimed |
| WO-2025098995-A1 | HEXOSAMINE BIOSYNTHETIC PATHWAYS'S INHIBITORS FOR USE IN THE TREATMENT OF CANCER | UNIVERSITA’ DEGLI STUDI DI MILANO-BICOCCA (IT) | 2025-05-15 | — | — | WO | claimed |
| US-4729999-A | MENOPAUSE, SIDE EFFECT PREVENTION | BCM TECHNOLOGIES (US) | 1988-03-08 | — | — | US | claimed |
| EP-0046270-B1 | NOVEL DERIVATIVES OF BIO-AFFECTING PHENOLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | INTERx RESEARCH CORPORATION (US) | 1986-05-21 | — | — | EP | claimed |
| EP-0069018-B1 | IODINE LABELLED RADIOACTIVE STILBENE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, AND THEIR USE IN RADIOIMMUNO ASSAYS | ROUSSEL-UCLAF (FR) | 1986-02-26 | — | — | EP | claimed |
| EP-0158476-A1 | Preparation of noroxymorphone from morphine | Mallinckrodt, Inc. (a Delaware corporation) (US) | 1985-10-16 | — | — | EP | claimed |
| US-4529713-A | Radioactive stilbene derivatives in radioimmunoassay | ROUSSEL UCLAF (FR) | 1985-07-16 | — | — | US | claimed |
| US-4526993-A | Reacting activated conjugated dienoic acid ester with alkali metal borohydride | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-07-02 | — | — | US | claimed |
| EP-0069018-A2 | Iodine labelled radioactive stilbene derivatives, process and intermediates for their preparation, and their use in radioimmuno assays | ROUSSEL-UCLAF (FR) | 1983-01-05 | — | — | EP | claimed |
| EP-0046270-A1 | Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them | INTERx RESEARCH CORPORATION (US) | 1982-02-24 | — | — | EP | claimed |
| US-4235236-A | Device for dispensing drug by combined diffusional and osmotic operations | ALZA CORPORATION (US) | 1980-11-25 | — | — | US | claimed |
| US-4087468-A | MAGNESIUM WITH ZINC, CADMIUM, MERCURY OR INDIUM HALIDE, AN ALIPHATIC HALIDE PROMOTER AND AN ETHER DILUENT | PHILLIPS PETROLEUM COMPANY (US) | 1978-05-02 | — | — | US | claimed |