Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dienestrol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 10/20 | 0.71 |
| ▸ | MAPT | P10636 | 6/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | TP53 | P04637 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.71 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.71 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dienestrol SCHEMBL2896848 | 0.84 | ESR1 (1.00) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL52170 | 0.84 | ESR1 (1.00) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL2896853 | 0.84 | ESR1 (1.00) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL6573104 | 0.82 | ESR1 (0.85) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL8425094 | 0.82 | ESR1 (0.85) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL9317394 | 0.82 | ESR1 (0.94) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL5689185 | 0.81 | ESR1 (0.61) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL114016 | 0.80 | ESR1 (0.81) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL3716190 | 0.80 | ESR1 (0.90) | ESR1MAPTLMNAHSD17B10MEN1 | |
| Dienestrol SCHEMBL5691782 | 0.79 | ESR1 (0.63) | ESR1MAPTLMNAHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597931-A | Total synthesis of taxol and analogues thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1997-01-28 | — | — | US | disclosed |
| WO-1996034862-A1 | TOTAL SYNTHESIS OF TAXOL AND ANALOGUES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1996-11-07 | — | — | WO | disclosed |
| US-5527924-A | ANTICARCINOGENIC AGENTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1996-06-18 | — | — | US | disclosed |
| US-5488116-A | Total synthesis of taxol and analogues thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1996-01-30 | — | — | US | disclosed |
| US-5416225-A | Chemical intermediates | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1995-05-16 | — | — | US | disclosed |
| WO-1995012567-A1 | TOTAL SYNTHESIS OF TAXOL AND ANALOGUES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1995-05-11 | — | — | WO | disclosed |
| WO-1993020036-A1 | TOTAL SYNTHESIS OF TAXOL | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-10-14 | — | — | WO | disclosed |