Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dienestrol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 7/20 | 0.81 |
| ▸ | MAPT | P10636 | 5/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.81 |
| ▸ | LMNA | P02545 | 4/20 | 0.81 |
| ▸ | MEN1 | O00255 | 3/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.81 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.81 |
| ▸ | TP53 | P04637 | 2/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.81 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.81 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.81 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.81 |
| ▸ | GAA | P10253 | 1/20 | 0.81 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.81 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dienestrol SCHEMBL2896848 | 0.90 | ESR1 (1.00) | ESR1MAPTHSD17B10LMNAMEN1 | |
| Dienestrol SCHEMBL2896853 | 0.90 | ESR1 (1.00) | ESR1MAPTHSD17B10LMNAMEN1 | |
| Dienestrol SCHEMBL52170 | 0.90 | ESR1 (1.00) | ESR1MAPTHSD17B10LMNAMEN1 | |
| Dienestrol SCHEMBL8425094 | 0.88 | ESR1 (0.85) | ESR1MAPTHSD17B10LMNAMEN1 | |
| Dienestrol SCHEMBL6573104 | 0.88 | ESR1 (0.85) | ESR1MAPTHSD17B10LMNAMEN1 | |
| Dienestrol SCHEMBL9317394 | 0.87 | ESR1 (0.94) | ESR1MAPTHSD17B10LMNAMEN1 | |
| Dienestrol SCHEMBL3716190 | 0.85 | ESR1 (0.90) | ESR1MAPTHSD17B10LMNAMEN1 | |
| SCHEMBL13492676 | 0.81 | MAPT (0.81) | ESR1MAPTHSD17B10LMNAMEN1 | |
| Dienestrol SCHEMBL8854079 | 0.80 | ESR1 (0.71) | ESR1MAPTHSD17B10LMNAMEN1 | |
| SCHEMBL15721373 | 0.80 | MAPT (0.71) | ESR1MAPTHSD17B10LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019076589-A1 | HYDROLYSIS-LABILE DIENOLSILYL ETHERS OF ODORANT KETONES OR ODORANT ALDEHYDES | HENKEL AG & CO. KGAA (DE) | 2019-04-25 | — | — | WO | claimed |
| EP-1638975-A2 | METHOD FOR PREPARING OXYCODONE | Boehringer Ingelheim Chemicals, Inc. (US) | 2006-03-29 | — | — | EP | claimed |
| JP-2004502637-A | — | — | 2004-01-29 | — | — | JP | claimed |
| US-20020143183-A1 | METHOD FOR PREPARING OXYCODONE | BOEHRINGER INGELHEIM CHEMICALS, INC. (US) | 2002-10-03 | — | — | US | claimed |
| US-6403798-B2 | PRODUCING A DIENOL ORGANOSILYL ETHER AT POSITION 6 OF THE C-RING OF CODEINONE THEREBY FORMING A DIENOL ORGANOSILYL ETHER CONGENER OF CODEINONE, OXIDIZING THE INTERMEDIATE TO FORM 14-HYDROXYCODEINONE, AND HYDROGENATING UNSATURATION | BOEHRINGER INGELHEIM CHEMICALS, INC. | 2002-06-11 | — | — | US | claimed |
| US-6262266-B1 | REACTING MORPHINAN-6-ONE COMPOUND WITH ORGANOSILYL COMPOUND IN PRESENCE OF STRONG AMINE BASE AND APROTIC SOLVENT | BOEHRINGER INGELHEIM CHEMICALS, INC. | 2001-07-17 | — | — | US | claimed |
| US-20010005754-A1 | Method for preparing oxycodone | CHIU FANG-TING (US) | 2001-06-28 | — | — | US | claimed |
| WO-2001029048-A2 | METHOD FOR PREPARING OXYCODONE | BOEHRINGER INGELHEIM CHEMICALS, INC. (US) | 2001-04-26 | — | — | WO | claimed |
| WO-2001029047-A2 | METHOD FOR PREPARING OXYCODONE | BOEHRINGER INGELHEIM CHEMICALS, INC. (US) | 2001-04-26 | — | — | WO | claimed |
| JP-11060587-A | — | — | None | — | — | JP | disclosed |
| CN-118290464-A | Preparation method of 1, 2-bis (trimethylsiloxy) cyclohexene | 杭州鑫富科技有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-115385837-A | Method for preparing astaxanthin through canthaxanthin oxidation | 万华化学集团股份有限公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-110551069-B | Synthesis method of 5-phenylpentanol compound and intermediate thereof | 中国科学院上海有机化学研究所 | 2022-10-04 | — | — | CN | disclosed |
| CN-114276247-A | 1,5-enyne ester chiral compound and synthesis method thereof | 华中师范大学 | 2022-04-05 | — | — | CN | disclosed |
| US-5416225-A | Chemical intermediates | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1995-05-16 | — | — | US | disclosed |
| WO-1995012567-A1 | TOTAL SYNTHESIS OF TAXOL AND ANALOGUES THEREOF | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1995-05-11 | — | — | WO | disclosed |
| WO-1993020036-A1 | TOTAL SYNTHESIS OF TAXOL | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1993-10-14 | — | — | WO | disclosed |
| US-5250710-A | Dihydropyran derivatives, processes for preparation and use | RHONE-POULENC NUTRITION ANIMALE (FR) | 1993-10-05 | — | — | US | disclosed |
| US-5157133-A | Vitamin A and E precursors | RHONE-POULENC NUTRITION ANIMALE (FR) | 1992-10-20 | — | — | US | disclosed |
| US-5126128-A | Pheromones | JAPAN TOBACCO INC. (JP) | 1992-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010005754-A1 | Method for preparing oxycodone | OPRK1, OPRM1, OPRD1 | ESR1 3016/4885MAPT 1928/4885HSD17B10 129/4885 |
| US-20020143183-A1 | METHOD FOR PREPARING OXYCODONE | OPRK1, OPRM1, OPRD1 | ESR1 3016/4885MAPT 1928/4885HSD17B10 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.