Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.55 |
| ▸ | BRD2 | P25440 | 6/20 | 0.55 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20946455 | 0.88 | BRD4 (0.57) | BRD4BRD2CREBBPFFAR1MAP4K4 | |
| SCHEMBL5218215 | 0.87 | MAP4K4 (0.64) | BRD4BRD2CREBBPTAAR1FFAR1 | |
| SCHEMBL12881340 | 0.87 | BRD4 (0.59) | BRD4BRD2CREBBPFFAR1BRD3 | |
| SCHEMBL3340053 | 0.83 | BRD4 (0.52) | BRD4BRD2CREBBPFFAR1BRD3 | |
| SCHEMBL3338755 | 0.83 | HTR7 (0.62) | BRD4BRD2CREBBPTAAR1FFAR1 | |
| SCHEMBL28047388 | 0.82 | BRD4 (0.57) | BRD4BRD2CREBBPFFAR1BRD3 | |
| SCHEMBL16675743 | 0.82 | BRD4 (0.58) | BRD4BRD2CREBBPFFAR1BRD3 | |
| SCHEMBL3339883 | 0.81 | BRD4 (0.53) | BRD4BRD2CREBBPFFAR1HTR7 | |
| SCHEMBL3336143 | 0.80 | BRD4 (0.52) | BRD4BRD2CREBBPFFAR1HTR7 | |
| SCHEMBL12866840 | 0.79 | BRD4 (0.57) | BRD4BRD2CREBBPFFAR1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581516-A4 | 3-HETEROCYCLIC BENZYLAMIDE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | BRISTOL MYERS SQUIBB CO (US) | 2007-10-17 | — | — | EP | disclosed |
| EP-1581516-A2 | 3-HETEROCYCLIC BENZYLAMIDE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004047744-A2 | 3-HETEROCYCLIC BENZYLAMIDE DERIVATIVES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |