⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10608921 | 0.81 | DUT (0.31) | — | |
| SCHEMBL10608918 | 0.81 | DUT (0.31) | — | |
| SCHEMBL14371399 | 0.80 | DUT (0.30) | — | |
| SCHEMBL12957404 | 0.80 | DUT (0.30) | — | |
| SCHEMBL10606545 | 0.79 | — | — | |
| SCHEMBL10606541 | 0.79 | — | — | |
| SCHEMBL10606539 | 0.79 | — | — | |
| SCHEMBL19090869 | 0.74 | TSHR (0.38) | — | |
| SCHEMBL9336985 | 0.74 | ALOX15 (0.31) | — | |
| SCHEMBL29217239 | 0.74 | ALOX15 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1852427-A1 | Biologically active 4H-Benzo [1,4] oxazin-3-ones | Ortho-McNeil Pharmaceutical, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| EP-1280784-B1 | BIOLOGICALLY ACTIVE 4H-BENZO 1,4|OXAZIN-3-ONES | ORTHO MCNEIL PHARM INC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-6908908-B2 | Biologically active 4H-benzo [1,4] oxazin-3-ones | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-06-21 | — | — | US | disclosed |
| US-6599899-B2 | 2-(2-(4-hexyl-3,4-dihydro-3-oxo-2H-1,4-benzoxazin-2-yl)ethoxy) - benzeneacetic acid for example; prophylaxis of onset of glucose or lipid metabolism disorders, such as non-insulin dependant diabetes mellitus or obesity | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-07-29 | — | — | US | disclosed |
| EP-1314729-A1 | Biologically active 4H-benzo(1,4)oxazin-3-ones | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-05-28 | — | — | EP | disclosed |
| US-20030083329-A1 | Biologically active 4H-benzo [1,4] oxazin-3-ones | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-05-01 | — | — | US | disclosed |
| US-6555536-B2 | Antiproliferative agents; antidiabetic agents | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-04-29 | — | — | US | disclosed |
| EP-1280784-A2 | BIOLOGICALLY ACTIVE 4H-BENZO 1,4]OXAZIN-3-ONES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-02-05 | — | — | EP | disclosed |
| EP-1280782-A2 | NOVEL BENZOXAZINONES AS PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA MODULATORS AND METHOD OF TREATMENT | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-02-05 | — | — | EP | disclosed |
| US-20020165228-A1 | Biologically active 4H-benzo [1,4]oxazin-3-ones | ORTH-MCNEIL PHARMACEUTICAL INC. | 2002-11-07 | — | — | US | disclosed |
| US-20020103193-A1 | Novel benzoxazinones as peroxisome proliferator activated receptor gamma modulators and method of treatment | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-08-01 | — | — | US | disclosed |
| WO-2001087862-A2 | BIOLOGICALLY ACTIVE 4H-BENZO[1,4]OXAZIN-3-ONES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-22 | — | — | WO | disclosed |
| WO-2001087860-A2 | NOVEL BENZOXAZINONES AS PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA MODULATORS AND METHOD OF TREATMENT | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-22 | — | — | WO | disclosed |