Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5094908 | 0.66 | MKNK1 (0.41) | CYP19A1CYP11B1CYP11B2USP2ALDH1A1 | |
| SCHEMBL5090858 | 0.65 | MKNK1 (0.41) | SLC6A2SLC6A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL23646289 | 0.61 | ADRA1D (0.57) | CYP19A1CYP11B1CYP11B2ALDH1A1HSD17B10 | |
| SCHEMBL5094873 | 0.61 | CYP1A2 (0.43) | CYP19A1CYP11B1CYP11B2USP2ALDH1A1 | |
| SCHEMBL10599652 | 0.59 | CA1 (0.42) | SLC6A2SLC6A4 | |
| SCHEMBL5120594 | 0.58 | CYP11B2 (0.42) | CYP19A1CYP11B1CYP11B2CYP1A2CYP3A4 | |
| SCHEMBL5094733 | 0.58 | MKNK1 (0.41) | CYP19A1CYP11B1CYP11B2USP2ALDH1A1 | |
| SCHEMBL1474674 | 0.58 | CHRM1 (0.48) | SLC6A2SLC6A4USP2ALDH1A1CYP1A2 | |
| SCHEMBL16445728 | 0.57 | MKNK1 (0.51) | SLC6A2SLC6A4CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL10599372 | 0.57 | SLC6A2 (0.39) | SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836196-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006069275-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-29 | — | — | WO | disclosed |