Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 8/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 3/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218666 | 1.00 | OPRM1 (0.34) | OPRM1OPRD1OPRK1TRPA1ABCB1 | |
| SCHEMBL5225796 | 0.94 | DPP8 (0.34) | OPRM1OPRD1OPRK1TRPA1ABCB1 | |
| SCHEMBL5225805 | 0.94 | DPP8 (0.34) | OPRM1OPRD1OPRK1TRPA1ABCB1 | |
| SCHEMBL5225802 | 0.94 | DPP8 (0.34) | OPRM1OPRD1OPRK1TRPA1ABCB1 | |
| SCHEMBL5222991 | 0.87 | EPHX2 (0.41) | — | |
| SCHEMBL5225985 | 0.83 | OPRM1 (0.35) | OPRM1OPRD1OPRK1TRPA1ABCB1 | |
| SCHEMBL5221296 | 0.83 | OPRM1 (0.35) | OPRM1OPRD1OPRK1TRPA1ABCB1 | |
| SCHEMBL5222763 | 0.83 | MME (0.36) | OPRM1OPRD1OPRK1TRPA1ABCB1 | |
| SCHEMBL5225992 | 0.83 | OPRM1 (0.35) | OPRM1OPRD1OPRK1TRPA1ABCB1 | |
| SCHEMBL5222750 | 0.83 | MME (0.36) | OPRM1OPRD1OPRK1TRPA1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |