Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214956 | 0.79 | CCR5 (0.52) | HTTALDH1A1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL5248494 | 0.75 | MEN1 (0.47) | KMT2AMEN1ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL8265529 | 0.74 | MEN1 (0.54) | KMT2AHTTMEN1MAPK1HPGD | |
| SCHEMBL7812842 | 0.73 | KMT2A (0.62) | KMT2AHTTMEN1MAPK1HPGD | |
| SCHEMBL7812819 | 0.72 | MAPK1 (0.66) | KMT2AHTTMEN1MAPK1HPGD | |
| SCHEMBL31676672 | 0.72 | HPGD (0.56) | KMT2AHTTMEN1MAPK1HPGD | |
| SCHEMBL5645943 | 0.72 | HPGD (0.56) | KMT2AHTTMEN1MAPK1HPGD | |
| SCHEMBL2187712 | 0.70 | MAPK1 (0.59) | KMT2AHTTMEN1MAPK1HPGD | |
| SCHEMBL20139425 | 0.68 | MEN1 (0.50) | KMT2AHTTMEN1MAPK1HPGD | |
| SCHEMBL2322279 | 0.68 | HPGD (0.59) | KMT2AHTTMEN1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831170-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006065204-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |