Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD5 | P21918 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4484633 | 0.78 | MEN1 (0.57) | MEN1KMT2AHRH1DRD1DRD4 | |
| SCHEMBL8265215 | 0.77 | BACE1 (0.45) | MEN1KMT2AHRH1DRD1DRD4 | |
| SCHEMBL4481567 | 0.76 | MEN1 (0.57) | MEN1KMT2AHRH1DRD1DRD4 | |
| SCHEMBL4478052 | 0.76 | MEN1 (0.61) | MEN1KMT2AHRH1DRD1DRD4 | |
| SCHEMBL5218860 | 0.75 | KMT2A (0.49) | MEN1KMT2AALDH1A1KDM4ECCR5 | |
| SCHEMBL5214956 | 0.74 | CCR5 (0.52) | LTA4HALDH1A1CCR5SMN1; SMN2 | |
| SCHEMBL20511573 | 0.73 | MEN1 (0.56) | MEN1KMT2ALTA4HPTGS2ALDH1A1 | |
| SCHEMBL2322967 | 0.72 | HTR1B (0.67) | MEN1KMT2ALTA4HPTGS2ALDH1A1 | |
| SCHEMBL2322996 | 0.71 | HRH3 (0.47) | TDP1HTR2AHTR2CHTR2B | |
| SCHEMBL2329109 | 0.70 | ALDH1A1 (0.67) | MEN1KMT2ALTA4HPTGS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831170-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006065204-A1 | SUBSTITUTED AMINOPYRIDINES AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-06-22 | — | — | WO | disclosed |