Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 8/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 3/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | IKBKB | O14920 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219353 | 0.86 | HTR4 (0.46) | HTR4SMYD3SMN1; SMN2HTR7ALOX15 | |
| SCHEMBL5244387 | 0.84 | HTR4 (0.46) | HTR4SMYD3SMN1; SMN2ALOX15 | |
| SCHEMBL5212984 | 0.77 | HTR4 (0.45) | HTR4SMN1; SMN2ALOX15CYP2D6CYP1A2 | |
| SCHEMBL5213618 | 0.75 | HTR4 (0.46) | HTR4SMYD3SMN1; SMN2ALOX15 | |
| SCHEMBL5215058 | 0.74 | HTR4 (0.48) | HTR4SMN1; SMN2ALOX15 | |
| SCHEMBL4375685 | 0.66 | HRH3 (0.50) | SMN1; SMN2CYP1A2 | |
| SCHEMBL4374850 | 0.66 | HRH3 (0.44) | SMN1; SMN2CYP1A2 | |
| SCHEMBL4378116 | 0.64 | HRH3 (0.54) | SMN1; SMN2CYP1A2 | |
| SCHEMBL5214688 | 0.64 | HTR4 (0.48) | HTR4SMYD3SMN1; SMN2ALOX15 | |
| SCHEMBL14375265 | 0.64 | HTR4 (0.45) | HTR4IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | claimed |
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |