Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 12/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219341 | 0.84 | HTR4 (0.46) | HTR4SMN1; SMN2SMYD3ALOX15 | |
| SCHEMBL5212984 | 0.81 | HTR4 (0.45) | HTR4SMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL5213618 | 0.79 | HTR4 (0.46) | HTR4SMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL5215058 | 0.78 | HTR4 (0.48) | HTR4SMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL5219353 | 0.73 | HTR4 (0.46) | HTR4SMN1; SMN2SMYD3ALOX15RAB9A | |
| SCHEMBL14417825 | 0.69 | L3MBTL1 (0.44) | SMN1; SMN2ALOX15RAB9A | |
| SCHEMBL14421884 | 0.68 | POLB (0.40) | SMN1; SMN2ALOX15 | |
| SCHEMBL14375265 | 0.68 | HTR4 (0.45) | HTR4RAB9A | |
| SCHEMBL5212995 | 0.68 | HTR4 (0.45) | HTR4SMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL14417840 | 0.68 | ALDH1A1 (0.33) | HTR4SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112270-B1 | DIHYDROBENZODIOXINE CARBOXAMIDE AND KETONE DERIVATIVES AS 5-HT4 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |