Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 7/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219776 | 0.96 | KDM4E (0.50) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5220487 | 0.86 | KDM4E (0.47) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5219772 | 0.84 | KDM4E (0.47) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5221138 | 0.83 | KDM4E (0.49) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5222480 | 0.82 | CTSD (0.44) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5224653 | 0.81 | MEN1 (0.44) | KDM4ESMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL5218030 | 0.79 | BACE1 (0.47) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL1479646 | 0.78 | KDM4E (0.48) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL5220082 | 0.78 | MEN1 (0.43) | KDM4ESMN1; SMN2ALDH1A1MAPTHPGD | |
| SCHEMBL1583553 | 0.77 | TP53 (0.52) | KDM4ENPC1RAB9ASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |