Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.38 |
| ▸ | CDK1 | P06493 | 6/20 | 0.36 |
| ▸ | CDK2 | P24941 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223792 | 0.75 | KMT2A (0.37) | POLBPIK3C3CDK1CDK2KDM4E | |
| SCHEMBL2738017 | 0.75 | TP53 (0.44) | POLBPIK3C3CDK1CDK2TP53 | |
| SCHEMBL6828695 | 0.75 | POLB (0.47) | POLBPIK3C3KDM4EMEN1KMT2A | |
| SCHEMBL30381157 | 0.73 | POLB (0.39) | POLBPIK3C3CDK1CDK2TP53 | |
| SCHEMBL14686943 | 0.70 | POLB (0.55) | POLBCDK1CDK2TP53 | |
| SCHEMBL5219375 | 0.70 | KDM4E (0.48) | PIK3C3KDM4EKMT2ATP53 | |
| SCHEMBL2806672 | 0.70 | KDM4E (0.59) | POLBKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL27711418 | 0.69 | POLB (0.41) | POLBPIK3C3CDK1CDK2TDP1 | |
| SCHEMBL1479429 | 0.69 | POLB (0.53) | POLBPIK3C3KDM4ETDP1TP53 | |
| SCHEMBL14687798 | 0.69 | POLB (0.53) | POLBPIK3C3CDK1CDK2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |