Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | WDR5 | P61964 | 3/20 | 0.33 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | RBBP5 | Q15291 | 1/20 | 0.31 |
| ▸ | ASH2L | Q9UBL3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221024 | 0.81 | PIK3C3 (0.35) | POLBPIK3C3TP53P2RX7 | |
| SCHEMBL5219385 | 0.75 | POLB (0.39) | KMT2APOLBKDM4EMEN1TDP1 | |
| SCHEMBL19149297 | 0.70 | KDM4E (0.55) | KMT2APOLBKDM4EMEN1TDP1 | |
| SCHEMBL5222493 | 0.69 | PIK3C3 (0.39) | POLBKDM4EPIK3C3TP53CDK1 | |
| SCHEMBL5222900 | 0.68 | CTSD (0.37) | POLBPIK3C3TP53CDK1CDK2 | |
| SCHEMBL30381157 | 0.68 | POLB (0.39) | POLBPIK3C3TP53CDK1CDK2 | |
| SCHEMBL5223174 | 0.68 | BACE1 (0.49) | POLBPIK3C3TP53 | |
| SCHEMBL14687798 | 0.67 | POLB (0.53) | POLBPIK3C3TP53CDK1CDK2 | |
| SCHEMBL14687626 | 0.67 | POLB (0.53) | POLBTP53CDK1CDK2P2RX7 | |
| SCHEMBL2738017 | 0.67 | TP53 (0.44) | POLBPIK3C3TP53CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |