Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 5/20 | 0.54 |
| ▸ | BCR | P11274 | 5/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10082535 | 0.86 | ABL1 (0.66) | GAAABL1BCRPDGFRBHDAC3 | |
| SCHEMBL5221060 | 0.85 | GAA (0.59) | GAAABL1BCRPDGFRBHDAC3 | |
| SCHEMBL4832910 | 0.80 | GAA (0.64) | GAAABL1BCRPDGFRBHDAC3 | |
| Cyclohexane SCHEMBL5218897 | 0.80 | GAA (0.69) | GAAABL1BCRPDGFRBHDAC3 | |
| SCHEMBL716370 | 0.79 | GAA (0.63) | GAAABL1BCRPDGFRBHDAC3 | |
| SCHEMBL4832914 | 0.79 | ABL1 (0.62) | GAAABL1BCRPDGFRBHDAC3 | |
| SCHEMBL27632593 | 0.78 | ABL1 (0.66) | GAAABL1BCRPDGFRBHDAC3 | |
| SCHEMBL4825993 | 0.78 | ABL1 (0.70) | GAAABL1BCRPDGFRBHDAC3 | |
| SCHEMBL715436 | 0.78 | GAA (0.61) | GAAABL1BCRPDGFRBHDAC3 | |
| SCHEMBL207468 | 0.77 | PTGS2 (0.77) | GAAMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525200-B1 | 2-(3-AMINOARYL)AMINO-4-ARYL-THIAZOLES AND THEIR USE AS C-KIT INHIBITORS | AB SCIENCE (FR) | 2007-10-10 | — | — | EP | claimed |