SCHEMBL5219650

SCHEMBL5219650

COC(=O)c1cc(NC(=O)CCCCl)c(OC)c([N+](=O)[O-])c1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.45
TPMT P51580 1/20 0.44
MAPK1 P28482 2/20 0.44
ALDH1A1 P00352 2/20 0.43
MAPT P10636 5/20 0.43
LMNA P02545 1/20 0.43
NPC1 O15118 1/20 0.41
POLB P06746 1/20 0.41
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
CRHBP P24387 1/20 0.41
CRHR2 Q13324 1/20 0.41
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5225589 0.87 ALDH1A1 (0.49) HTTALDH1A1MAPTLMNANPC1
SCHEMBL5217023 0.87 ALDH1A1 (0.46) ALDH1A1MAPTLMNAPOLBMEN1
SCHEMBL5220531 0.80 VCAM1 (0.43) HTTTPMTMAPK1ALDH1A1MAPT
SCHEMBL5218309 0.79 VCAM1 (0.42) HTTTPMTMAPK1ALDH1A1MAPT
SCHEMBL5224165 0.78 ALDH1A1 (0.47) MAPK1ALDH1A1MAPTNPC1POLB
SCHEMBL5216905 0.77 TPMT (0.64) HTTTPMTMAPK1ALDH1A1MAPT
SCHEMBL5404138 0.76 ALDH1A1 (0.45) HTTTPMTALDH1A1MAPTLMNA
SCHEMBL5216830 0.75 MAPT (0.49) HTTALDH1A1MAPTLMNAPOLB
SCHEMBL4892239 0.73 TPMT (0.56) HTTTPMTMAPK1ALDH1A1MAPT
SCHEMBL5219656 0.73 ALDH1A1 (0.42) TPMTALDH1A1MAPTLMNANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1567488-B1 HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE GLAXO GROUP LTD (GB) 2007-02-21 EP disclosed