Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.67 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.67 |
| ▸ | MMP12 | P39900 | 2/20 | 0.67 |
| ▸ | MMP3 | P08254 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6595866 | 0.92 | ADAM17 (0.64) | MMP2ADAM17MMP12MMP3 | |
| SCHEMBL6598271 | 0.87 | ADAM17 (0.68) | MMP2ADAM17MMP12MMP3 | |
| SCHEMBL6596288 | 0.86 | ADAM17 (0.69) | MMP2ADAM17MMP12MMP3 | |
| SCHEMBL6595704 | 0.86 | ADAM17 (0.69) | MMP2ADAM17MMP12MMP3 | |
| SCHEMBL7404737 | 0.82 | ADAM17 (0.53) | MMP2ADAM17MMP12MMP3 | |
| SCHEMBL6598962 | 0.82 | ADAM17 (0.71) | MMP2ADAM17MMP12 | |
| SCHEMBL6594802 | 0.82 | ADAM17 (0.71) | MMP2ADAM17MMP12MMP3 | |
| SCHEMBL3968857 | 0.82 | MMP2 (0.80) | MMP2ADAM17MMP12MMP3 | |
| SCHEMBL1504768 | 0.82 | ADAM17 (0.64) | MMP2ADAM17MMP12MMP3 | |
| SCHEMBL6598171 | 0.82 | ADAM17 (0.71) | MMP2ADAM17MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558581-A4 | TRIAZOLONE AND TRIAZOLETHIONE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2007-07-25 | — | — | EP | disclosed |
| US-7074810-B2 | Triazolone and triazolethione derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1558581-A2 | TRIAZOLONE AND TRIAZOLETHIONE DERIVATIVES | Bristol-Myers Squibb Company (US) | 2005-08-03 | — | — | EP | disclosed |
| US-20040116491-A1 | Triazolone and triazolethione derivatives as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-17 | — | — | US | disclosed |
| WO-2004032846-A2 | TRIAZOLONE AND TRIAZOLETHIONE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-04-22 | — | — | WO | disclosed |