Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 6/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218338 | 0.97 | POLB (0.46) | POLBTP53BACE1CTSDBACE2 | |
| SCHEMBL5220117 | 0.89 | BACE1 (0.37) | POLBBACE1CTSDBACE2CYP19A1 | |
| SCHEMBL5220039 | 0.88 | TP53 (0.39) | POLBTP53BACE1CTSDBACE2 | |
| SCHEMBL5218348 | 0.85 | BACE1 (0.37) | POLBBACE1CTSDBACE2SMN1; SMN2 | |
| SCHEMBL5222266 | 0.85 | KDM4E (0.38) | POLBTP53BACE1CTSDBACE2 | |
| SCHEMBL5219134 | 0.79 | POLB (0.39) | POLBTP53BACE1CTSDBACE2 | |
| SCHEMBL5222594 | 0.79 | POLB (0.39) | POLBTP53BACE1CTSDBACE2 | |
| SCHEMBL5389474 | 0.78 | TP53 (0.38) | POLBTP53MAPTSMN1; SMN2 | |
| SCHEMBL5220034 | 0.77 | BACE1 (0.37) | POLBTP53BACE1CTSDBACE2 | |
| SCHEMBL5225090 | 0.77 | BACE1 (0.53) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |