Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | RHEB | Q15382 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | HPGD | P15428 | 4/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5218348 | 0.97 | BACE1 (0.37) | BACE1CTSDBACE2CYP19A1DRD3 | |
| SCHEMBL5220119 | 0.89 | POLB (0.42) | BACE1CTSDBACE2CYP19A1DRD3 | |
| SCHEMBL5220034 | 0.88 | BACE1 (0.37) | BACE1CTSDBACE2POLBKDM4E | |
| SCHEMBL5218338 | 0.85 | POLB (0.46) | BACE1CTSDBACE2CYP19A1DRD3 | |
| SCHEMBL5222272 | 0.85 | BACE1 (0.37) | BACE1CTSDBACE2POLBKDM4E | |
| SCHEMBL5222586 | 0.79 | CTSD (0.37) | BACE1CTSDBACE2KDM4EALDH1A1 | |
| SCHEMBL5225090 | 0.77 | BACE1 (0.53) | BACE1CTSDBACE2KDM4EALDH1A1 | |
| SCHEMBL5217639 | 0.76 | CTSD (0.37) | BACE1CTSDBACE2POLBHPGD | |
| SCHEMBL308351 | 0.75 | NPC1 (0.44) | POLBKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5219142 | 0.74 | BACE1 (0.58) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |