Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 6/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222586 | 0.89 | CTSD (0.37) | CTSDBACE1BACE2HTTPTGER3 | |
| SCHEMBL5218380 | 0.88 | PIK3C3 (0.39) | PIK3C3CTSDBACE1BACE2PTGER3 | |
| SCHEMBL5220119 | 0.79 | POLB (0.42) | POLBPIK3C3CTSDBACE1BACE2 | |
| SCHEMBL5218370 | 0.78 | PTGER3 (0.37) | CTSDBACE1BACE2PTGER3MAPT | |
| SCHEMBL5219279 | 0.77 | CTSD (0.51) | CTSDBACE1BACE2PTGER3 | |
| SCHEMBL5221378 | 0.76 | BACE1 (0.55) | CTSDBACE1BACE2 | |
| SCHEMBL5219134 | 0.76 | POLB (0.39) | POLBPIK3C3CTSDBACE1BACE2 | |
| SCHEMBL5218338 | 0.76 | POLB (0.46) | POLBCTSDBACE1BACE2TP53 | |
| SCHEMBL5218450 | 0.73 | BACE1 (0.61) | CTSDBACE1BACE2 | |
| SCHEMBL5217621 | 0.72 | POLB (0.43) | POLBPIK3C3CTSDBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |