Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215845 | 0.82 | AOC3 (0.44) | AOC3SLC6A4SLC6A2SLC6A3IDO1 | |
| SCHEMBL8171991 | 0.82 | CYP19A1 (0.38) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL16993614 | 0.81 | FFAR1 (0.50) | AOC3LMNASMN1; SMN2FFAR1UTS2R | |
| SCHEMBL2065578 | 0.81 | GSR (0.47) | LMNASLC6A4 | |
| SCHEMBL2065580 | 0.81 | GSR (0.47) | LMNASLC6A4 | |
| SCHEMBL1155354 | 0.81 | AOC3 (0.58) | AOC3LMNASMN1; SMN2UTS2RADRB2 | |
| SCHEMBL7490605 | 0.76 | AOC3 (0.45) | AOC3ADRB2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5159898 | 0.72 | AOC3 (0.41) | AOC3LMNASMN1; SMN2FFAR1UTS2R | |
| SCHEMBL1155183 | 0.72 | LMNA (0.36) | AOC3LMNASMN1; SMN2ADRB2SLC6A4 | |
| SCHEMBL5159911 | 0.72 | AOC3 (0.41) | AOC3LMNASMN1; SMN2FFAR1UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765810-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | Decode Chemistry, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123724-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | DECODE CHEMISTRY, INC. (US) | 2005-12-29 | — | — | WO | disclosed |