SCHEMBL5220468

SCHEMBL5220468

COC(=O)[C@H]1CCC(=O)[C@@H]1c1ccc(F)cc1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 10/20 0.46
SLC6A4 P31645 4/20 0.43
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA4 P22748 1/20 0.43
CA7 P43166 1/20 0.43
SLC6A2 P23975 3/20 0.42
TDP1 Q9NUW8 1/20 0.42
RECQL P46063 1/20 0.39
KDM4E B2RXH2 1/20 0.39
LMNA P02545 1/20 0.39
MAPK1 P28482 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5216002 1.00 SLC6A3 (0.46) SLC6A3SLC6A4CA1CA2CA4
SCHEMBL5215996 1.00 SLC6A3 (0.46) SLC6A3SLC6A4CA1CA2CA4
SCHEMBL5221669 0.85 SLC6A2 (0.49) SLC6A3SLC6A4SLC6A2MAPK1SMN1; SMN2
SCHEMBL5221675 0.85 SLC6A2 (0.49) SLC6A3SLC6A4SLC6A2MAPK1SMN1; SMN2
SCHEMBL22831008 0.77 SLC6A2 (0.50) SLC6A3SLC6A4SLC6A2MAPK1SMN1; SMN2
SCHEMBL22831009 0.77 SLC6A2 (0.50) SLC6A3SLC6A4SLC6A2MAPK1SMN1; SMN2
SCHEMBL22831007 0.77 SLC6A2 (0.50) SLC6A3SLC6A4SLC6A2MAPK1SMN1; SMN2
SCHEMBL4983554 0.76 LMNA (0.39) SLC6A3RECQLLMNA
SCHEMBL3477143 0.76 LMNA (0.39) SLC6A3RECQLLMNA
SCHEMBL31335433 0.75 SLC6A3 (0.36) SLC6A3SLC6A4SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1322596-B1 ZWITTERIONIC TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2007-08-15 EP disclosed
EP-1226146-A2 QUINOLINE AND NAPHTHYRIDINE CARBOXYLIC ACID ANTIBACTERIALS ABBOTT LABORATORIES (US) 2002-07-31 EP disclosed
WO-2001032655-A2 QUINOLINE AND NAPHTHYRIDINE CARBOXYLIC ACID ANTIBACTERIALS ABBOTT LABORATORIES (US) 2001-05-10 WO disclosed
US-5929094-A NOVEL 3-((SUBSTITUTED) HETEROCYCLE),6-(SUBSTITUTED PHENYL)-1-OXASPIRO(4.4)NONANE DERIVATIVES; ANTAGONIZING THE EFFECT OF SUBSTANCE P BY ADMINISTERING TO BLOCK NEUROKININ-1 RECEPTORS; TREATING INFLAMMATION, MIGRAINE, EMESIS AND ASTHMA MERCK & CO., INC. (US) 1999-07-27 US disclosed
US-5877191-A ANTIINFLAMMATORY AGENT; ANALGESICS; ANTIHISTAMINES; EMESIS MERCK & CO., INC. (US) 1999-03-02 US disclosed
US-5750549-A ANTIINFLAMMATORY AGENTS OR ANALGESICS MERCK & CO., INC. (US) 1998-05-12 US disclosed
WO-1998017276-A1 HETEROARYL SPIROETHERCYCLOALKYL TACHYKININ RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1998-04-30 WO disclosed