SCHEMBL5220805

SCHEMBL5220805

Cn1cc(C(=O)c2ccc(F)cc2)cc1C(=O)c1cccnc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 2/20 0.50
ALDH1A1 P00352 1/20 0.46
MAPT P10636 3/20 0.46
LMNA P02545 1/20 0.46
TSHR P16473 1/20 0.46
MAPK1 P28482 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC10 Q969S8 1/20 0.45
HDAC11 Q96DB2 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
HDAC9 Q9UKV0 1/20 0.45
HDAC5 Q9UQL6 1/20 0.45
KMT2A Q03164 1/20 0.45
LTA4H P09960 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5219306 0.99 ATM (0.49) ATMALDH1A1MAPTLMNATSHR
Hydrochloric Acid SCHEMBL5307392 0.85 HTT (0.45) ALDH1A1MAPTLMNATSHRMAPK1
SCHEMBL29691445 0.82 LTA4H (0.63) ATMALDH1A1MAPTHDAC1HDAC6
SCHEMBL7802228 0.82 LTA4H (0.63) ATMALDH1A1MAPTHDAC1HDAC6
SCHEMBL7225284 0.75 HTT (0.41) ALDH1A1MAPTLMNAMAPK1GAA
SCHEMBL5216771 0.72 HTT (0.52) MAPTLMNATSHRMAPK1SMN1; SMN2
Hydrochloric Acid SCHEMBL5220509 0.72 HDAC3 (0.47) ATMALDH1A1MAPTLMNAHDAC3
SCHEMBL10487075 0.72 ALDH1A1 (0.53) ATMALDH1A1HDAC1HDAC6KMT2A
SCHEMBL18228619 0.71 ALDH1A1 (0.49) ALDH1A1LMNATSHRSMN1; SMN2HDAC1
SCHEMBL5219619 0.71 ALDH1A1 (0.49) ALDH1A1LMNATSHRMAPK1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1458386-B1 AROYL PYRROLE HETEROERYL AND METHANOLS USEFUL FOR TREATING A CENTRAL NERVOUS SYSTEM DISORDER ORTHO MCNEIL PHARM INC (US) 2007-04-18 EP claimed