Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217075 | 0.90 | NPC1 (0.48) | POLBALDH1A1HPGDLMNANPC1 | |
| SCHEMBL3274531 | 0.80 | ATR (0.52) | POLBALDH1A1HPGDHTTLMNA | |
| SCHEMBL23093425 | 0.76 | CCR4 (0.39) | ALDH1A1HPGDHTTUSP2HDAC3 | |
| Hydrochloric Acid SCHEMBL5221890 | 0.73 | GSK3B (0.55) | POLBALDH1A1HTTSMN1; SMN2GAA | |
| SCHEMBL3280676 | 0.73 | NPC1 (0.53) | ALDH1A1HPGDLMNANPC1RAB9A | |
| SCHEMBL23093156 | 0.72 | EGFR (0.49) | ALDH1A1LMNASMN1; SMN2USP2HDAC3 | |
| SCHEMBL23499144 | 0.71 | ALDH1A1 (0.41) | POLBALDH1A1HPGDHTTLMNA | |
| SCHEMBL15890234 | 0.70 | HPGD (0.60) | POLBALDH1A1HPGDHTTLMNA | |
| SCHEMBL5217722 | 0.70 | ALDH1A1 (0.41) | POLBALDH1A1HPGDHTTLMNA | |
| SCHEMBL33527951 | 0.69 | POLB (0.64) | POLBALDH1A1HPGDHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575942-B1 | COMPOUNDS HAVING SELECTIVE INHIBITING EFECT AT GSK3 | ASTRAZENECA AB (SE) | 2007-05-02 | — | — | EP | claimed |