Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221777 | 0.88 | ALDH1A1 (0.40) | LMNAHPGDTSHRUSP2CYP1A2 | |
| SCHEMBL5216498 | 0.84 | BACE1 (0.47) | LMNAHPGDTSHRCYP1A2CYP3A4 | |
| SCHEMBL5219064 | 0.82 | HSD17B10 (0.42) | LMNAHPGDTSHRCYP1A2CYP3A4 | |
| SCHEMBL5851474 | 0.82 | SMN1; SMN2 (0.42) | LMNAHPGDTSHRCYP1A2CYP3A4 | |
| SCHEMBL5216170 | 0.81 | HSD17B10 (0.41) | LMNAHPGDTSHRCYP3A4CYP2C9 | |
| SCHEMBL5853141 | 0.79 | CFTR (0.41) | LMNAHPGDTSHRCYP1A2CYP3A4 | |
| SCHEMBL5222867 | 0.78 | HSD17B10 (0.36) | LMNAHPGDTSHRCYP3A4CYP2C9 | |
| SCHEMBL5222872 | 0.78 | HSD17B10 (0.36) | LMNAHPGDTSHRCYP3A4CYP2C9 | |
| SCHEMBL5222877 | 0.78 | HSD17B10 (0.36) | LMNAHPGDTSHRCYP3A4CYP2C9 | |
| SCHEMBL5223450 | 0.77 | ALDH1A1 (0.46) | LMNAALDH1A1POLBGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |