Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5939919 | 0.81 | MAPT (0.49) | KMT2ATSHRHTR1ASLC6A4NOTUM | |
| SCHEMBL10490569 | 0.80 | HTR1A (0.55) | KMT2ATSHRHTR1ASLC6A4NOTUM | |
| SCHEMBL11805707 | 0.80 | HTR1A (0.52) | KMT2ATSHRHTR1ASLC6A4NOTUM | |
| SCHEMBL15157267 | 0.80 | KMT2A (0.69) | KMT2ATSHRNOTUMPOLBMAPT | |
| SCHEMBL31306532 | 0.80 | KMT2A (0.69) | KMT2ATSHRNOTUMPOLBMAPT | |
| SCHEMBL4972560 | 0.80 | RAB9A (0.61) | NOTUMSLC22A12MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL9247991 | 0.79 | HTR1A (0.56) | KMT2ATSHRHTR1ASLC6A4NOTUM | |
| SCHEMBL25396424 | 0.77 | KMT2A (0.40) | KMT2ATSHRSLC22A12POLBMAPT | |
| SCHEMBL1858436 | 0.77 | HTR1A (0.54) | KMT2ATSHRHTR1ASLC6A4NOTUM | |
| SCHEMBL4970006 | 0.77 | RAB9A (0.61) | KMT2ANOTUMSLC22A12POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1852427-A1 | Biologically active 4H-Benzo [1,4] oxazin-3-ones | Ortho-McNeil Pharmaceutical, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| EP-1280784-B1 | BIOLOGICALLY ACTIVE 4H-BENZO 1,4|OXAZIN-3-ONES | ORTHO MCNEIL PHARM INC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-6908908-B2 | Biologically active 4H-benzo [1,4] oxazin-3-ones | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-06-21 | — | — | US | disclosed |
| EP-1314729-A1 | Biologically active 4H-benzo(1,4)oxazin-3-ones | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-05-28 | — | — | EP | disclosed |
| US-20030083329-A1 | Biologically active 4H-benzo [1,4] oxazin-3-ones | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-05-01 | — | — | US | disclosed |
| US-6555536-B2 | Antiproliferative agents; antidiabetic agents | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-04-29 | — | — | US | disclosed |
| EP-1280784-A2 | BIOLOGICALLY ACTIVE 4H-BENZO 1,4]OXAZIN-3-ONES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-02-05 | — | — | EP | disclosed |
| US-20020165228-A1 | Biologically active 4H-benzo [1,4]oxazin-3-ones | ORTH-MCNEIL PHARMACEUTICAL INC. | 2002-11-07 | — | — | US | disclosed |
| WO-2001087862-A2 | BIOLOGICALLY ACTIVE 4H-BENZO[1,4]OXAZIN-3-ONES | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083329-A1 | Biologically active 4H-benzo [1,4] oxazin-3-ones | PPARD, PPARA, PPARG | KMT2A 3579/4885TSHR 1547/4885HTR1A 1076/4885 |
| US-20020165228-A1 | Biologically active 4H-benzo [1,4]oxazin-3-ones | PPARD, PPARA, PPARG | KMT2A 3579/4885TSHR 1547/4885HTR1A 1076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.