Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MDH1 | P40925 | 1/20 | 0.35 |
| ▸ | MDH2 | P40926 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221511 | 0.78 | ALDH1A1 (0.39) | KDM4EHSD17B10TSHRMEN1KMT2A | |
| SCHEMBL5224165 | 0.76 | ALDH1A1 (0.47) | KDM4EHSD17B10TSHRMEN1KMT2A | |
| SCHEMBL15910578 | 0.75 | KDM4E (0.48) | KDM4EHSD17B10TSHRMEN1GAA | |
| SCHEMBL5221959 | 0.75 | KDM4E (0.41) | KDM4EHSD17B10TSHRMEN1GAA | |
| SCHEMBL5217023 | 0.75 | ALDH1A1 (0.46) | KDM4EHSD17B10TSHRMEN1KMT2A | |
| SCHEMBL5221268 | 0.74 | PTGER3 (0.35) | KDM4EHSD17B10TSHRMEN1GAA | |
| SCHEMBL5222170 | 0.72 | ALDH1A1 (0.42) | KDM4EHSD17B10TSHRALDH1A1HPGD | |
| SCHEMBL5223269 | 0.71 | KDM4E (0.49) | KDM4EHSD17B10TSHRMEN1GAA | |
| SCHEMBL475604 | 0.70 | ALDH1A1 (0.53) | KDM4EHSD17B10MEN1GAAKMT2A | |
| SCHEMBL5220585 | 0.70 | ALDH1A1 (0.63) | KDM4EHSD17B10TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |
| CN-1735592-A | Hydroxyethylamine derivatives for the treatment of alzheimer's disease | GLAXO GROUP LTD (GB) | 2006-02-15 | — | — | CN | disclosed |