Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MDH1 | P40925 | 1/20 | 0.35 |
| ▸ | MDH2 | P40926 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221827 | 0.78 | KDM4E (0.41) | ALDH1A1KDM4EATMHSD17B10HPGD | |
| SCHEMBL5219842 | 0.78 | KDM4E (0.40) | ALDH1A1KDM4EATMHSD17B10HPGD | |
| SCHEMBL5217023 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KDM4EATMHSD17B10HPGD | |
| SCHEMBL309368 | 0.76 | KDM4E (0.41) | ALDH1A1KDM4EHSD17B10SMN1; SMN2POLB | |
| SCHEMBL5224165 | 0.76 | ALDH1A1 (0.47) | ALDH1A1KDM4EATMHSD17B10HPGD | |
| SCHEMBL5217329 | 0.74 | YTHDC1 (0.34) | ALDH1A1KDM4ESMN1; SMN2POLBTDP1 | |
| SCHEMBL5221529 | 0.73 | ALDH1A1 (0.39) | ALDH1A1KDM4EATMHSD17B10HPGD | |
| SCHEMBL5218276 | 0.71 | KDM4E (0.52) | ALDH1A1KDM4EHPGDSMN1; SMN2POLB | |
| SCHEMBL475604 | 0.70 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL5220585 | 0.70 | ALDH1A1 (0.63) | ALDH1A1KDM4EATMHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |