Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222278 | 0.90 | CTSD (0.48) | HSD17B10PKMMAPTL3MBTL1KDM4E | |
| SCHEMBL5222117 | 0.88 | CTSD (0.42) | HSD17B10PKMMAPTL3MBTL1KDM4E | |
| SCHEMBL5219361 | 0.87 | GAA (0.44) | HSD17B10SMN1; SMN2CTSDBACE1BACE2 | |
| SCHEMBL5221500 | 0.87 | CTSD (0.46) | HSD17B10PKMMAPTL3MBTL1KDM4E | |
| SCHEMBL5221504 | 0.78 | CTSD (0.51) | HSD17B10CTSDBACE1BACE2MEN1 | |
| SCHEMBL5221970 | 0.76 | CTSD (0.49) | HSD17B10CTSDBACE1BACE2MEN1 | |
| SCHEMBL5219479 | 0.76 | CA12 (0.45) | HSD17B10MAPTL3MBTL1KDM4EALOX15 | |
| SCHEMBL5220175 | 0.75 | CTSD (0.48) | HSD17B10PKMMAPTL3MBTL1KDM4E | |
| SCHEMBL5220565 | 0.74 | CTSD (0.42) | HSD17B10L3MBTL1KDM4ESMN1; SMN2CTSD | |
| SCHEMBL25351074 | 0.73 | HSD17B10 (0.44) | HSD17B10PKMMAPTL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |