SCHEMBL5221926

SCHEMBL5221926

Cc1c(C(=O)O)ccc(S(C)(=O)=O)c1C1=NOC(CCl)C1

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MIF P14174 8/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
LMNA P02545 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6677226 0.91 NPC1 (0.37) MIFNPC1RAB9AHDAC6
SCHEMBL7242122 0.89 NPC1 (0.38) MIFNPC1RAB9ALMNA
SCHEMBL6679350 0.82 NPC1 (0.31) NPC1RAB9A
SCHEMBL7230119 0.82 NPC1 (0.31) MIFNPC1RAB9A
SCHEMBL7059813 0.80 NPC1 (0.30) NPC1RAB9A
SCHEMBL5213876 0.80 MIF (0.33) MIFNPC1RAB9A
SCHEMBL7539968 0.77
SCHEMBL7232919 0.76
SCHEMBL29429101 0.74 GABRP (0.31) LMNA
SCHEMBL4698411 0.74 GABRP (0.31) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1286991-B1 CYCLOPROPYL-ANELLATED 3-(4,5-DIHYDROISOXAZOL-3-YL)-SUBSTITUED BENZOYLPYRAZOLES BASF AG (DE) 2007-06-06 EP disclosed
EP-1237881-B1 HERBICIDAL HALOGENALKYL-SUBSTITUTED 3-(4,5-DIHYDROISOXAZOL-3-YL)-BENZOYL-CYCLOHEXENONES BASF AG (DE) 2004-11-03 EP disclosed
US-6627581-B1 Herbicide; acylating a pyrazole with a benzoic acid derivative BASF AKTIENGESELLSCHAFT (DE) 2003-09-30 US disclosed
US-6599860-B1 Methods for controlling undesirable vegetation using the compounds BASF AKTIENGESELLSCHAFT (DE) 2003-07-29 US disclosed