Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 13/20 | 0.57 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.57 |
| ▸ | CTSD | P07339 | 4/20 | 0.57 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5222041 | 1.00 | BACE1 (0.57) | BACE1BACE2CTSDSLC1A1ADRB2 | |
| SCHEMBL5221435 | 0.89 | BACE1 (0.49) | BACE1BACE2CTSD | |
| SCHEMBL5221442 | 0.89 | BACE1 (0.49) | BACE1BACE2CTSD | |
| SCHEMBL5223736 | 0.88 | BACE1 (0.57) | BACE1BACE2CTSDADRB2ADRB1 | |
| SCHEMBL5223728 | 0.88 | BACE1 (0.57) | BACE1BACE2CTSDADRB2ADRB1 | |
| SCHEMBL5393980 | 0.81 | CTSD (0.44) | BACE1BACE2CTSDSLC1A1ADRB2 | |
| Hydrochloric Acid SCHEMBL5217734 | 0.81 | CTSD (0.43) | BACE1BACE2CTSDSLC1A1ADRB2 | |
| SCHEMBL4262818 | 0.79 | BACE1 (0.52) | BACE1BACE2CTSD | |
| SCHEMBL7613268 | 0.74 | BACE1 (0.59) | BACE1BACE2CTSDBCHE | |
| SCHEMBL7613279 | 0.74 | BACE1 (0.59) | BACE1BACE2CTSDBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |