Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.57 |
| ▸ | CTSD | P07339 | 2/20 | 0.57 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.57 |
| ▸ | CTSV | O60911 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5223736 | 1.00 | BACE1 (0.57) | BACE1CTSDBACE2CTSVCTSL | |
| SCHEMBL5222034 | 0.88 | BACE1 (0.57) | BACE1CTSDBACE2ADRB1ADRB2 | |
| SCHEMBL5222041 | 0.88 | BACE1 (0.57) | BACE1CTSDBACE2ADRB1ADRB2 | |
| SCHEMBL5400529 | 0.81 | PNMT (0.49) | BACE1CTSDBACE2ADRB3ADRB1 | |
| SCHEMBL5221442 | 0.81 | BACE1 (0.49) | BACE1CTSDBACE2 | |
| Hydrochloric Acid SCHEMBL5221937 | 0.81 | PNMT (0.48) | BACE1CTSDBACE2ADRB3ADRB1 | |
| SCHEMBL5221435 | 0.81 | BACE1 (0.49) | BACE1CTSDBACE2 | |
| SCHEMBL6894836 | 0.74 | BACE1 (0.58) | BACE1CTSDBACE2F2 | |
| SCHEMBL7607624 | 0.74 | BACE1 (0.58) | BACE1CTSDBACE2F2 | |
| SCHEMBL7607629 | 0.74 | BACE1 (0.58) | BACE1CTSDBACE2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |