Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL4465616 | 0.99 | NPC1 (0.37) | NPC1CYP11B1CYP11B2GRM2IL4I1 | |
| SCHEMBL2678187 | 0.97 | NPC1 (0.39) | NPC1CYP11B1CYP11B2GRM2IL4I1 | |
| SCHEMBL2677959 | 0.95 | NPC1 (0.41) | NPC1CYP11B1CYP11B2GRM2IL4I1 | |
| SCHEMBL5221954 | 0.84 | NSD2 (0.32) | — | |
| Bromide SCHEMBL4478970 | 0.83 | NSD2 (0.32) | — | |
| SCHEMBL2679286 | 0.82 | AKT1 (0.36) | NPC1 | |
| SCHEMBL4463296 | 0.82 | HSD11B1 (0.40) | HSD11B1NPY5R | |
| SCHEMBL2678934 | 0.81 | CYP11B1 (0.41) | CYP11B1CYP11B2L3MBTL1 | |
| Bromide SCHEMBL4471147 | 0.81 | HSD11B1 (0.39) | HSD11B1NPY5R | |
| SCHEMBL2679352 | 0.80 | MAPT (0.36) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465893-B1 | DERIVATIVES OF 5-(PYRIDIN-3-YL)-1-AZABICYCLO (3.2.1) OCTANE, THE PREPARATION THEREOF AND THE APPLICATION OF SAME IN THERAPEUTICS | SANOFI AVENTIS (FR) | 2007-02-28 | — | — | EP | claimed |