Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | CA5A | P35218 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16146941 | 0.81 | CES1 (0.57) | TDP1CA1CA2CA5ACA9 | |
| SCHEMBL13199203 | 0.81 | GRB2 (0.57) | CES1CES2SRD5A2RAB9AALDH1A1 | |
| SCHEMBL2812395 | 0.78 | TDP1 (0.53) | TDP1CA1CA2CES1HSD11B1 | |
| SCHEMBL4286706 | 0.78 | HSD11B1 (0.57) | TDP1CA1CA2CA5ACA9 | |
| SCHEMBL10879986 | 0.78 | TDP1 (0.53) | TDP1CA1CA2CES1HSD11B1 | |
| SCHEMBL439543 | 0.77 | CA1 (0.60) | CA1CA2CA5ACA9HSD11B1 | |
| SCHEMBL7912766 | 0.77 | TDP1 (0.52) | TDP1CA1CA2CES1HSD11B1 | |
| SCHEMBL1646651 | 0.77 | TDP1 (0.52) | TDP1CA1CA2CES1HSD11B1 | |
| SCHEMBL3530264 | 0.77 | TDP1 (0.52) | TDP1CA1CA2CES1HSD11B1 | |
| SCHEMBL11690409 | 0.77 | CYP1A2 (0.55) | TDP1CA1CA2CA5ACA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8802886-B2 | Method for producing aromatic difluoroacetic acid ester | CENTRAL GLASS COMPANY, LIMITED (JP) | 2014-08-12 | — | — | US | disclosed |
| US-8802886-B2 | Method for producing aromatic difluoroacetic acid ester | CENTRAL GLASS COMPANY, LIMITED (JP) | 2014-08-12 | — | — | US | disclosed |
| US-8802886-B2 | Method for producing aromatic difluoroacetic acid ester | CENTRAL GLASS COMPANY, LIMITED (JP) | 2014-08-12 | — | — | US | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| EP-2502898-A1 | PREPARATION METHOD FOR AROMATIC DIFLUOROACETIC ACID ESTER | Central Glass Company, Limited (JP) | 2012-09-26 | — | — | EP | disclosed |
| US-20120220795-A1 | METHOD FOR PRODUCING AROMATIC DIFLUOROACETIC ACID ESTER | CENTRAL GLASS COMPANY, LIMITED (JP) | 2012-08-30 | — | — | US | disclosed |
| US-20120220795-A1 | METHOD FOR PRODUCING AROMATIC DIFLUOROACETIC ACID ESTER | CENTRAL GLASS COMPANY, LIMITED (JP) | 2012-08-30 | — | — | US | disclosed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220795-A1 | METHOD FOR PRODUCING AROMATIC DIFLUOROACETIC ACID ESTER | DDC, AADAC, FNTB | TDP1 4760/4885CA1 115/4885CA2 184/4885 |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | TDP1 1698/4885CA1 4430/4885CA2 1560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.